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Enantioselective inhibition of ampomorphine-induced emesis in the ferret by the neurokinin1receptor antagonist CP-99,994

Authors
Journal
Neuropharmacology
0028-3908
Publisher
Elsevier
Publication Date
Volume
33
Issue
2
Identifiers
DOI: 10.1016/0028-3908(94)90018-3
Keywords
  • Anti-Emetic
  • Cp-99
  • 994
  • Ferrets
  • Apomorphine-Induced Emesis
  • Neurokinin1Receptor
  • Vomiting

Abstract

Abstract These studies have examined the effects of the selective neurokinini 1 (NK 1) receptor antagonist CP-99,994 on the retching and vomiting response to apomorphine. CP-99,994 (1–3 mg/kg i.p.) attenuated retching and vomiting induced by apomorphine (0.25 mg/kg s.c.) with complete inhibition of retching and vomiting at the 3 mg/kg dose. In contrast CP-100,263 (3 mg/kg i.p.), the enantiomer of CP-99,994 with 1000-fold lower affinity for the NK 1 receptor, was without effect.

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