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Sister Joseph's nodule in a liver transplant recipient: Case report and mini-review of literature

Authors
Publisher
BioMed Central
Publication Date
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PMC
Keywords
  • Review
Disciplines
  • Medicine

Abstract

1477-7819-3-4.fm ral World Journal of Surgical Oncology ss BioMed Cent Open AcceReview Sister Joseph's nodule in a liver transplant recipient: Case report and mini-review of literature Fabrizio Panaro*1, Enzo Andorno1, Stefano Di Domenico1, Nicola Morelli1, Giuliano Bottino1, Rosalia Mondello1, Marco Miggino1, Tomasz M Jarzembowski2, Ferruccio Ravazzoni1, Marco Casaccia1 and Umberto Valente1 Address: 1Department of Transplant Surgery, St. Martino Hospital-University of Genoa, Genoa, Italy and 2University of Illinois at Chicago, Department of Surgery, Division of Transplantation, Chicago, IL. USA Email: Fabrizio Panaro* - [email protected]; Enzo Andorno - [email protected]; Stefano Di Domenico - [email protected]; Nicola Morelli - [email protected]; Giuliano Bottino - [email protected]; Rosalia Mondello - [email protected]; Marco Miggino - [email protected]; Tomasz M Jarzembowski - [email protected]; Ferruccio Ravazzoni - [email protected]; Marco Casaccia - [email protected]; Umberto Valente - [email protected] * Corresponding author Abstract Background: Umbilical metastasis is one of the main characteristic signs of extensive neoplastic disease and is universally referred to as Sister Mary Joseph's nodule. Case presentation: A 59-years-old Caucasian female underwent liver transplant for end stage liver disease due to hepatitis C with whole graft from cadaveric donor in 2003. After transplantation the patient developed multiple subcutaneous nodules in the umbilical region and bilateral inguinal lymphadenopathy. The excision biopsy of the umbilical mass showed the features of a poorly differentiated papillary serous cystadenocarcinoma. Computed tomographic scan and transvaginal ultrasonography were unable to demonstrate any primary lesion. Chemotherapy was start and the dosage of the immunosuppre

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