A comprehensive algorithm has been developed to design and optimize heat-driven thermoacoustic refrigeration (HDTAR)systems. This algorithm is applied to design and optimize a HDTAR capable of providing 30 w of cooling power at 2°C. The computer code DeltaE is used to simulate the device. The HDTAR has the total length of 1.25 m and the cross sectional area of 0.012m 2. The results indicate that since HDTAR devices utilize the available waste heat from the automotive engine to cool down the automotive interior, even at relatively low efficiency these devices could still reduce the amount of fuel used in the conventional automotive air conditioning systems.