Affordable Access

Publisher Website

Transplantation hépatique pour carcinome hépatocellulaire

Authors
Journal
Cancer/Radiothérapie
1278-3218
Publisher
Elsevier
Publication Date
Volume
9
Identifiers
DOI: 10.1016/j.canrad.2005.09.009
Keywords
  • Transplantation Hépatique
  • Carcinome Hépatocellulaire
  • Liver Transplantation
  • Hepatocellular Carcinoma
Disciplines
  • Medicine

Abstract

Abstract Hepatocellular carcinoma (HCC) is the most frequent primitive cancer of the liver. It mostly develops on cirrhotic livers. Orthotopic liver transplantation is the only treatment that definitively addresses both the metachronous occurrence risk of HCC and the underlying disease. Under Milan criteria, i.e. less than 3 nodules of 3 cm max in diameter, or 1 nodule of 5 cm maximum, OLT has been shown effective and provides with survival rates almost equal to those obtained with HCC free cirrhotic patients. In Rennes, 195 patients with early HCC on cirrhotic livers have been transplanted from January 1995 to June 2005. Global and disease free 8 years patient survival rates were 73 and 70%, respectively. These results were significantly altered when the recipient was female, the cirrhosis due to C virus and the patient of B blood group. Despite these excellent results, the principal limit to the application of transplantation for HCC remains the long period of time patients have to wait for a graft. During this period of time, growth of the tumour may drop the patient out of Milan criteria and subsequently from the waiting list. The role of chemoembolisation, liver resection and thermal ablation while the patient is waiting for a graft remains debatable.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

P.116 Intérêt de la TEP au18FDG dans l’évaluation...

on Gastroentérologie Clinique et... Jan 01, 2009

Résultats à long terme de la résection hépatique p...

on Journal de Chirurgie Viscérale Jan 01, 2010
More articles like this..