Abstract This study aimed to evaluate the effects of the annealing temperature on the structural evolution and mechanical properties of TiZrAlV alloy. The microstructural evolution and mechanical properties of the alloy were investigated by X-ray diffraction, metallographic analysis, tensile testing, and microhardness testing. The results showed that the thickness of the α phase that precipitated from the parent phase was sensitive to the annealing temperature. With increased annealing temperature, the α-phase tended to exhibit equiaxed grains, except for the specimen annealed at 1050°C. The tensile strength of the equiaxed α grains were also demonstrated to have higher tensile strength than those of the lamellar α phase. The optimal mechanical properties of the alloy was obtained after annealing at 850°C, i.e., σb=1245MPa, σ0.2=1006MPa, and ε=16.89%.