Affordable Access

The effect of subfebrile doses of bacterial pyrogens on splanchnic metabolism and cardiac output

Journal of Laboratory and Clinical Medicine
Publication Date
  • Clinical And Experimental


Abstract Subfebrile doses of bacterial pyrogens have been found to produce striking alterations in splanchnic circulation and metabolism. These consisted of a mean decrease in Bromsulphalein clearance of 33 per cent, a mean elevation of hepatic blood flow of 47 per cent, and a rise in mean splanchnic oxygen consumption of 18 per cent. Splanchnic glucose production was unaffected. The elevation of hepatic blood flow was not accompanied by proportionate increase in cardiac output. Contamination of parenterally injected materials with small amounts of bacterial pyrogens is, therefore, suggested as a possible cause for erratic alterations of splanchnic metabolism.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

The effect of subfebrile doses of bacterial pyroge...

on Journal of Laboratory and Clin... April 1955

Studies of cardiac output and of blood flow and me...

on Transactions of the Associatio... 1950

Effect of graded doses of insulin on splanchnic an...

on The American journal of physio... May 1980

Effects of beta-adrenergic agonists on splanchnic...

on The American journal of physio... November 1991
More articles like this..