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Mast cell signaling: The role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
584
Issue
24
Identifiers
DOI: 10.1016/j.febslet.2010.08.006
Keywords
  • Mast Cell
  • FcεRi Signal Transduction
  • Syk
  • Fyn
  • Gab2
  • Phosphatase
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract The aggregation by antigen of the IgE bound to its high affinity receptor on mast cells initiates a complex series of biochemical events that result in the release of inflammatory mediators. The essential role of the protein tyrosine kinase Syk has been appreciated for some time, and newer results have defined the mechanism of its activation. The use of siRNA has defined the relative contribution of Syk, Fyn and Gab2 to signaling and has made possible a screening study to identify previously unrecognized molecules that are involved in these pathways.

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