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Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion.

Authors
  • 1
Type
Published Article
Journal
PLoS neglected tropical diseases
1935-2735
Publication Date
Volume
5
Issue
2
Identifiers
DOI: 10.1371/journal.pntd.0000953
PMID: 21408103
Source
Medline

Abstract

These data highlight, for the first time, that LDLr is involved in host cell invasion by this parasite and the subsequent fusion of the parasitophorous vacuole with the host cell lysosomal compartment. The model suggested by this study unifies previous models of host cell invasion for this pathogenic protozoon. Overall, these data indicate that T. cruzi targets LDLr and its family members during invasion. Binding to LDL likely facilitates parasite entry into host cells. The observations in this report suggest that therapeutic strategies based on the interaction of T. cruzi and the LDLr pathway should be pursued as possible targets to modify the pathogenesis of disease following infection.

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