Affordable Access

Publisher Website

PD-1 and its ligands in T-cell immunity

Authors
Journal
Current Opinion in Immunology
0952-7915
Publisher
Elsevier
Publication Date
Volume
19
Issue
3
Identifiers
DOI: 10.1016/j.coi.2007.04.012

Abstract

The past year has seen significant advances in our understanding of the critical roles of negative immunoregulatory signals delivered by the programmed death 1 (PD-1)–PD-1 ligand (PD-L) pathway in regulating T-cell activation and tolerance. Emerging evidence indicates that PD-Ls play an essential role on dendritic cells (DCs), both directly during DC–T cell interactions and indirectly through signaling into the DC. Recent studies point to a novel role for PD-L1 in maintaining tissue tolerance. Finally, PD-1 has recently been shown to be highly expressed on exhausted T cells during chronic viral infection, and blockade of PD-1 or PD-L1 can revive exhausted T cells, enabling them to proliferate and produce effector cytokines.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

PD-1 and its ligands in T-cell immunity.

on Current Opinion in Immunology June 2007

PD-1 and its ligands in tolerance and immunity.

on Annual Review of Immunology 2008

PD184352 releases the regular hypoxic reversible D...

on Journal of biochemistry and mo... Nov 30, 2007
More articles like this..