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Relationship between the rate of erythrocyte hexose monophosphate pathway and the glucose 6-phosphate concentration

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
125
Issue
1
Identifiers
DOI: 10.1016/s0006-291x(84)80326-5

Abstract

Summary Erythrocytes of individuals with increased (+ 50%) or reduced (−35%) hexokinase activity contain respectively 70 and 17 nmole/ml RBC of glucose-6-phosphate (normal concentration 30±5nmole/ml RBC) and show comparable rates of the HMP (60±5nmole/hr/ml RBC). Similarly, in RBC of different ages, obtained by density gradient ultracentrifugation, the glucose-6-phosphate concentration range from 57 (young cells) to 18 (old cells) nmole/ml RBC but the rate at which glucose is utilized in the HMP is unchanged. These data exclude a regulatory role of glucose 6-phosphate in the HMP even if its concentration is under that required for maximal G6PD activity.

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