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Formation of a factor lethal for S. Typhimurium TA1530 and TA1531 on incubation of aflatoxin B1with rat liver microsomes

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
45
Issue
3
Identifiers
DOI: 10.1016/0006-291x(71)90484-0
Disciplines
  • Biology

Abstract

Abstract Strains TA1530 and TA1531, but not strains C207 and G46, of S. typhimurium (1) were killed when incubated with rat liver homogenate and aflatoxin B 1 but not with either component alone. The lethal effect required the microsomal fraction of liver, was dependent on O 2 and NADPH, and was inhibited by the addition of aniline, SKF-525A, or CO. Less of the lethal factor was formed with liver preparations from rats fed a low protein diet, and more was formed if the rats were administered phenobarbital. Aflatoxin M 1 (4-hydroxy aflatoxin B 1) was not toxic for these bacterial strains in the absence of liver preparations and was much less toxic than aflatoxin B 1 when incubated with rat liver.

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