Affordable Access

Publisher Website

An alternative procedure for calculating glucose consumption from 2-deoxyglucose uptake

Authors
Journal
Bulletin of Mathematical Biology
0092-8240
Publisher
Springer-Verlag
Publication Date
Volume
51
Issue
2
Identifiers
DOI: 10.1016/s0092-8240(89)80073-4

Abstract

In the commonly used model (Sokoloff) for the transport and metabolism of glucose and 2-deoxyglucose in brain tissue a novel choice of constant parameters is proposed. In particular, the maximal transport capacity for glucose is assumed proportional to the rate of glucose consumption. The proportionality factor, the “transport factor”, may be calculated from the lumped constant and is more likely than the latter to remain constant under varying conditions. Calculations founded on these considerations should yield results similar to the Sokoloff procedure in many situations, but differences appear when the arterial glucose concentration changes. The model is flexible and allows changes.

There are no comments yet on this publication. Be the first to share your thoughts.