Affordable Access

Publisher Website

Mycobacterium tuberculosis ftsHexpression in response to stress and viability

Authors
Journal
Tuberculosis
1472-9792
Publisher
Elsevier
Publication Date
Volume
89
Identifiers
DOI: 10.1016/s1472-9792(09)70016-2
Keywords
  • Ftsz
  • Ftsh
  • Cell Division
  • Mycobacterium Tuberculosis
  • Stress
Disciplines
  • Biology

Abstract

Summary FtsH is an essential membrane-bound protease that degrades integral membrane proteins as well as cytoplasmic proteins. We show that Mycobacterium tuberculosis (Mtb) ftsH expression levels are upregulated upon exposure to agents that produce reactive oxygen and nitrogen intermediates (ROI and RNI) and growth in macrophages. In partial support of this result is our observation that the Mtb merodiploid overexpressing ftsH shows increased resistance to ROI. ftsH transcript levels are downregulated during stationary phase and starvation. ftsH overexpression strain shows delayed growth and reduced viability in vitro and ex vivo. Finally, we show that the intracellular levels of FtsZ, an essential cell-division protein, are reduced in ftsH-overexpressing strain. Together, our results suggest that Mtb FtsH is a stress-response protein that promotes the pathogen's ability to deal with ROI stress and is possibly involved in the regulation of FtsZ levels.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Mycobacterium tuberculosis ftsH expression in resp...

on Tuberculosis (Edinburgh, Scotl... December 2009

Viability of stressed Mycobacterium tuberculosis a...

on Brazilian Journal of Microbiol... Jan 01, 2013

Viability of stressed Mycobacterium tuberculosis a...

on Brazilian Journal of Microbiol... 2013

Mycobacterium Tuberculosis Response to Stress from...

on Frontiers in Microbiology Jan 01, 2011
More articles like this..