Affordable Access

Cardiac tamponade and constrictive pericarditis. II. Treatment.

Authors
Publication Date
Source
PMC
Keywords
  • Research Article
Disciplines
  • Biology
  • Chemistry
  • Ecology
  • Geography
  • Medicine

Abstract

Cardiac Sarcoidosis What is Cardiac Sarcoidosis? Sarcoidosis is a poorly understood disease that commonly affects the lungs. It can also involve the lymph nodes, liver, spleen, eyes, skin, bones, salivary glands and heart. Cardiac sarcoidosis (CS) is estimated to be present in 10-25% of people with sarcoidosis. Sarcoidosis is characterized by the presence of granulomas. These are ball-like collections of white blood cells that cluster around and react to a foreign substance. The inflammation associated with granulomas can damage every part of the heart, including the electrical system, muscle, valves, arteries and surrounding tissue called the pericardium. It is important to remember CS can precede, follow, or occur as the same time as other non-cardiac forms of sarcoid. What causes Cardiac Sarcoidosis? The exact cause of sarcoidosis is unknown. Granulomas appear to be the result of an immune system response to an unidentified trigger. Infectious agents as well as environmental exposures are thought to be possible precipitants for this immune response. Genetic mutations in white blood cell proteins (called human leukocyte antigens, or HLA) as well as chemicals that control inflammation (called cytokines) have also been linked to sarcoidosis. How can Sarcoidosis affect the Heart? Cardiac sarcoidosis can take many forms, some benign and others serious. These include: Heart Rhythm Disorders: A complete block of electrical movement through the heart is the most common form of CS. Alternatively, fast heart rhythms such as atrial flutter, atrial fibrillation, supraventricular tachycardia, and ventricular tachycardia can be present. Ventricular tachycardia occurs in almost 25% of people with CS and is concerning since it can lead to sudden cardiac death. Heart Failure: Heart failure is the second most common form of CS. Sarcoidosis can cause the heart muscle to weaken and/or stiffen. This leads to fluid retention

There are no comments yet on this publication. Be the first to share your thoughts.