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The central corticotropin-releasing factor and glucagon-like peptide-1 in food intake of the neonatal chick

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
339
Identifiers
DOI: 10.1016/s0014-2999(97)01391-5
Keywords
  • Glp-1 (Glucagon-Like Peptide-1)
  • Crf (Corticotropin-Releasing Factor)
  • Hypothalamic-Pituitary-Adrenal Axis
  • Feeding Behavior
  • (Chicken)

Abstract

Abstract Recently, we have reported that central administration of glucagon-like peptide-1 (GLP-1) strongly decreases food intake of chicks. The aim of this study was to elucidate whether suppressed food intake induced by the central injection of GLP-1 is mediated by activation of the hypothalamic-pituitary-adrenal axis. First, the effects of central administration of corticotropin-releasing factor (CRF) were investigated. Birds (2-day-old) were food-deprived for 3 h and then CRF or saline was injected intracerebroventricular (i.c.v.). CRF strongly inhibited food intake. Thereafter, effects of central CRF or GLP-1 on plasma corticosterone concentration were examined. CRF significantly stimulated corticosterone release, but GLP-1 did not alter plasma corticosterone concentration. These results suggest that CRF is a potent inhibitor of food intake in the chick, but the suppression of food intake induced by central GLP-1 may not be involved in the activation of hypothalamic-pituitary-adrenal axis.

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