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Collagenase and proteinase induction in implants of bone matrix

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
49
Issue
3
Identifiers
DOI: 10.1016/0006-291x(72)90475-5
Disciplines
  • Biology

Abstract

Abstract Enzymes capable of digesting collagen and non-collagenous proteins are present in implants of bone matrix. In the early stages of bone morphogenesis, implants produce relatively large amounts of trypsin-labile proteins and have high non-collagenolytic neutral proteinase and low collagenase activities. Enzymatic activity is maximal three weeks after implantation. The results indicate that increased synthesis of non-collagenous proteins and non-collagenolytic proteinases precedes the induction of significant amounts of collagenases. The importance of these findings in bone morphogenesis is discussed.

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