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Suitability of the beagle dog as a test model for the tumorigenic potential of contraceptive steroids “short review”

Authors
Journal
Contraception
0010-7824
Publisher
Elsevier
Publication Date
Volume
20
Issue
3
Identifiers
DOI: 10.1016/0010-7824(79)90096-9
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The purpose of this short review is to assess the present state of knowledge on the suitability of the beagle dog as a test model for the tumorigenic potential of contraceptive steroids. The beagle dog differs markedly from other species, including man, as regards its reproductive physiology and endocrinology. Studies on the influence of contraceptive steroids on canine mammary gland, pituitary gland and uterus have led to the conclusion that the stimulation of development of mammary tumours in dogs by certain progestagens or progestagen-oestrogen combinations must be considered as being a species-specific effect, related to the high hormonal potency (progestational activity) of these compounds in the dog and their stimulatory effect on canine growth hormone. Based on the present state of our knowledge and because of the marked interspecies differences of action of contraceptive steroids in dog and man, the steroid-related canine mammary tumours, especially with regard to the doses necessary for contraception, are unlikely to be indicative of a potential hazard to the human female.

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