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Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems.

Authors
  • 1
Type
Published Article
Journal
Environmental health perspectives
1552-9924
Publication Date
Volume
117
Issue
4
Pages
545–551
Identifiers
DOI: 10.1289/ehp.11728
PMID: 19440492
Source
Medline
Keywords
  • Extracellular Receptor Kinase
  • Gap-Junctional Intercellular Communication
  • Mitogen-Activated Protein Kinase
  • Perfluorooctanoate
  • Perfluoropentanoate
  • Phosphatidylcholine-Specific-Phospholipase C
  • Tumor Promotion

Abstract

The in vitro analysis of GJIC, an epigenetic marker of tumor promoters, can also predict the in vivo activity of PFOA, which dysregulated GJIC via ERK and PC-PLC.

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