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Capturing the Regenerative Potential of Periodontal Ligament Fibroblasts

Journal of Stem cells and Regenerative medicine
Publication Date
  • Brief Communication
  • Medicine


Original Article JSRM/Vol7 No.1, 2011; p 54 ‐56 Copyright © Journal of Stem cells and Regenerative medicine. All rights reserved JSRM/007010400006/Apr 01, 2011 JSRM/Vol7 No.1, 2011; p54‐56 ‐ 54‐ Vol7 issue.1 Brief Communication Capturing the Regenerative Potential of Periodontal Ligament Fibroblasts Christina Springstead Scanlon (1), Julie Teresa Marchesan (1), Stephen Soehren (1), Masato Matsuo (2), Yvonne L. Kapila (1) ______________________________________________________________ (1) Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI 48109 (2) Department of Oral Anatomy, Kanagawa Dental College, Yokosuka, Kanagawa, 238-8580, Japan Keyword: PDL, fibroblast, culture The cell population within the periodontal ligament (PDL) tissue is remarkably heterogeneous1. Fibroblasts, a mixed population of cells, are the main cellular component of the PDL and the cell type most often studied for periodontal regeneration. Osteoblasts and osteoclasts are found on the bone side, while fibroblasts, macrophages, undifferentiated adult/mesenchymal stem cells, neural elements, and endothelial cells are found throughout the PDL. Epithelial rests of Malassez cells and cementoblasts are focused near the root surface. PDL tissue also includes loose connective tissue between dense fiber bundles that contain branches of the periodontal blood vessels and nerves2. The complexity of the PDL tissue, with its various cell types and cell progenitor components, explains the challenges involved in therapies to restore tissue following periodontal disease. Cementoblasts, osteoblasts, and endothelial cells must migrate, differentiate, and coordinately interact w

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