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Thrombolytic Therapy in Acute Stroke: Outcome, Barriers & How to Overcome

Bangladesh Society of Medicine
Publication Date
  • Medicine
  • Thrombolytic Therapy
  • Biology
  • Economics
  • Medicine
  • Pharmacology


Vol-14 (1) 2013 JBSM.pmd Introduction Stroke is the leading cause of disability among adults globally. Despite advances in preventive strategies and initial therapy for stroke, nearly 800,000strokes occur per year in the United States and 87% of all strokes worldwide areischemic in origin.1 As recently as less than 10 years ago, management of acute ischemic stroke consisted of diagnosis, medical support & rehabilitation after acute event. There are now interventions for acute revascularization, either pharmacological or mechanical, that allow blood follow to be restored promptly to the ischemic brain tissue.2,3 It is also one of the leading cause of death in our country. But there has been limited progress in management of patientswith stroke in developing countries and data on stroke care inthese countries are sparse.4,5,6 Guidelines are continuouslydeveloped and updated in the developed world but theirpracticality for use in developing regions is unrealistic 6.The number of stroke patients receiving r-tPA in the thirdworld is extremely low. In Stroke thrombolysis is currentlyused in few developing countries like Brazil, Argentina,Senegal, Iran, Pakistan, China, Thailand, and India.7 Sadly, thrombolysis is still underused in our country. Purpose of this review is to highlight the positive results of thromblytic therapy in acute stroke which willencourage our physician to offer this therapy to an increasing number of stroke patients, and thereby reduce the considerable socioeconomic burden of stroke. Role of Thrombolytic therapy Ischemic stroke results from vascular occlusion that reduces cerebral blood flowto the area of brain perfused by the occluded artery. In either thrombotic or embolicstroke, such Review Article J MEDICINE 2013; 14 : 65-69 Thrombolytic Therapy in Acute Stroke: Outcome, Barriers & How to Overcome HAM NAZMUL AHASAN,1 MD. YEANUR HOSSAIN2,APARNA DAS3, BAHARUL MINNAT4, MOSTOFA KAMAL CHOWDHURY5 1. Profe

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