Affordable Access

Publisher Website

Divergent solid-phase synthesis of nucleic acid dendrimers

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
39
Issue
11
Identifiers
DOI: 10.1016/s0040-4039(97)10871-1

Abstract

Abstract A divergent or “starburst” approach for the construction of branched nucleic acids mimicking naturally occuring lariat and forked introns is described. Chain assembly takes place on the surface of controlled-pore glass solid support in the unconventional 5′ to 3′ direction. The branch junctures were introduced by use of N 6-benzoyl-2′,3′-O-bis(dimethoxytrityl)adenosine-5′-O-(N,N-diisopropyl)-β-cyanoethylphosphoramidite. Various dendrimers were prepared in comparable or better yields relative to the convergent approach.

There are no comments yet on this publication. Be the first to share your thoughts.