Affordable Access

Publisher Website

Divergent solid-phase synthesis of nucleic acid dendrimers

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
39
Issue
11
Identifiers
DOI: 10.1016/s0040-4039(97)10871-1

Abstract

Abstract A divergent or “starburst” approach for the construction of branched nucleic acids mimicking naturally occuring lariat and forked introns is described. Chain assembly takes place on the surface of controlled-pore glass solid support in the unconventional 5′ to 3′ direction. The branch junctures were introduced by use of N 6-benzoyl-2′,3′-O-bis(dimethoxytrityl)adenosine-5′-O-(N,N-diisopropyl)-β-cyanoethylphosphoramidite. Various dendrimers were prepared in comparable or better yields relative to the convergent approach.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments