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Dual purpose contraceptives: targeting fertility and sexually transmitted disease

Authors
Publisher
Elsevier Ireland Ltd
Publication Date
Keywords
  • 110700 Immunology
  • Contraception
  • Sexually Transmitted Disease
  • Chlamydia
Disciplines
  • Biology
  • Medicine

Abstract

i DEVELOPMENT OF NOVEL VACCINE STRATEGIES TO PREVENT GENITAL TRACT CHLAMYDIAL INFECTIONS Alison Jane Carey B. Science (Hons) A thesis submitted in partial fulfillment of the requirements for the degree of Doctorate of Philosophy Institute of Health & Biomedical Innovation Faculty of Science & Technology Queensland University of Technology Brisbane, QLD, Australia 2010 ii iii ABSTRACT Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection in the developed world and the leading cause of preventable blindness worldwide. As reported by the World Health Organization in 2001, there are approximately 92 million new infections detected annually, costing health systems billions of dollars to treat not only the acute infection, but also to treat infection-associated sequelae. The majority of genital infections are asymptomatic, with 50-70% going undetected. Genital tract infections can be easily treated with antibiotics when detected. Lack of treatment can lead to the development of pelvic inflammatory disease, ectopic pregnancies and tubal factor infertility in women and epididymitis and prostatitis in men. With infection rates on the continual rise and the large number of infections going undetected, there is a need to develop an efficacious vaccine which prevents not only infection, but also the development of infection-associated pathology. Before a vaccine can be developed and administered, the pathogenesis of chlamydial infections needs to be fully understood. This includes the kinetics of ascending infection and the effects of inoculating dose on ascension and development of pathology. The first aim in this study was to examine these factors in a murine model. Female BALB/c mice were infected intravaginally with varying doses of C. muridarum, the mouse varia

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