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Locus control regions: coming of age at a decade plus

Authors
Journal
Trends in Genetics
0168-9525
Publisher
Elsevier
Publication Date
Volume
15
Issue
10
Identifiers
DOI: 10.1016/s0168-9525(99)01780-1
Keywords
  • Locus Control Regions
  • β Globin Locus
  • Transcription
  • Gene Regulation
  • Chromatin Conformation
  • Hypersensitive Sites
  • Position Effect

Abstract

Abstract The β-globin locus control region (LCR) is the founding member of a novel class of cis-acting regulatory elements that confer high level, tissue-specific, site-of-integration-independent, copy number-dependent expression on linked transgenes located in ectopic chromatin sites. Knowledge from β-globin and other LCR studies has shed light on our understanding of the long-range interaction between enhancers and promoters, the relationship between chromatin conformation and transcriptional regulation, and the developmental regulation of multiple gene loci. After over a decade of investigation and discovery, we take a retrospective look at the β-globin LCR and other LCRs, summarize their properties and review models of LCR function.

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