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Metabolic risk factor profile associated with use of second generation antipsychotics: a cross sectional study in a community mental health centre

Authors
Publisher
BioMed Central
Publication Date
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PMC
Keywords
  • Research Article
Disciplines
  • Medicine
  • Psychology

Abstract

1471-244X-6-11.fm ral ss BioMed CentBMC Psychiatry Open AcceResearch article Metabolic risk factor profile associated with use of second generation antipsychotics: a cross sectional study in a community mental health centre Ilaria Tarricone, Michela Casoria, Beatrice Ferrari Gozzi, Daniela Grieco, Marco Menchetti, Alessandro Serretti, Manjola Ujkaj, Francesca Pastorelli and Domenico Berardi* Address: Institute of Psychiatry, Bologna University, Viale C. Pepoli 5, 40123 Bologna, Italy Email: Ilaria Tarricone - [email protected]; Michela Casoria - [email protected]; Beatrice Ferrari Gozzi - [email protected]; Daniela Grieco - [email protected]; Marco Menchetti - [email protected]; Alessandro Serretti - [email protected]; Manjola Ujkaj - [email protected]; Francesca Pastorelli - [email protected]; Domenico Berardi* - [email protected] * Corresponding author Abstract Background: Second generation antipsychotics (SGA) have demonstrated several advantages over first generation antipsychotics (FGA) in terms of positive, negative, cognitive, and affective symptoms and a lower propensity for extrapyramidal side effects. Despite these undeniable advantages, SGA have been associated with causing and exacerbating metabolic disorders, such as obesity, diabetes, and hyperlipidemia. This cross sectional study aimed to evaluate the metabolic risk factor profile associated with use of SGAs in comparison with non - treated control patients. Methods: The study was carried out at a Community Mental Health Centre (CMHC) in Bologna. The study subjects were outpatients with serious mental disorders treated with SGA (clozapine, olanzapine, risperidone, quetiapine). A sample of adult men and women suffering from idiopathic hyperhydrosis, without psychiatric history or antipsychotic treatment, were randomly selected from outpatients of the Department of Neurology in Bologna as a reference group. We investigated differences among the treatment and

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