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A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier.

Authors
  • 1
Type
Published Article
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
3
Issue
6
Identifiers
DOI: 10.1371/journal.pone.0002469
PMID: 18575595
Source
Medline

Abstract

This study provides the initial proof of concept for p97 as a carrier capable of shuttling therapeutic levels of drugs from the blood to the brain for the treatment of neurological disorders, including classes of resident and metastatic brain tumors. It may be prudent, therefore, to consider implementation of this novel delivery platform in various clinical settings for therapeutic intervention in acute and chronic neurological diseases.

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