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Quantitative immunoligical studies on single amino acid substitution in human hemoglobin: Demonstration of specific antibodies to

Authors
Journal
Immunochemistry
0019-2791
Publisher
Elsevier
Publication Date
Volume
11
Issue
1
Identifiers
DOI: 10.1016/0019-2791(74)90338-3
Disciplines
  • Medicine

Abstract

Abstract Rabbit antibodies have been elicited to many mutant human hemoglobins. These antimutant sera distinguish A 1 hemoglobin from the mutant hemoglobins more regularly and by larger quantitative differences than these immunological distinction are made by rabbit A 1 sera. Of 14 variant hemoglobins injected into rabbits, 12 regularly elicited mutant specific antibodies. These data are discussed in terms of a hypothesis relating binding energy differences between A 1 and mutant hbs reacting with specific antibody and the amino acid sequence differences known to exist between human and rabbit hemoglobins.

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