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Effect of prostaglandin E1on hepatic cyclic AMP activity, carbohydrate and lipid metabolism

Authors
Journal
Prostaglandins & Other Lipid Mediators
0090-6980
Publisher
Elsevier
Publication Date
Volume
6
Issue
6
Identifiers
DOI: 10.1016/s0090-6980(74)80061-4
Disciplines
  • Biology

Abstract

Abstract Prostaglandin E 1 (PGE 1) failed to stimulate rat liver cyclic AMP (cAMP), induce hyperglycemia, glycogenolysis or lipolysis or prevent epinephrine-induced hyperglycemia in isolated perfused rat liver, even though other known glycogenolytic agents (glucagon and epinephrine) activated cAMP in this same system. The data do not support a physiologic role for PGE 1 on hepatic glycogenolysis or lipolysis. Although the effects of PGE 1 on gluconeogenesis, lipogenesis, ureogenesis or amino acid transport in isolated perfused liver were not investigated, if PGE 1 is subsequently found to influence these metabolic parameters, such alterations would probably occur independent of a change in cAMP activity.

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