Affordable Access

Publisher Website

Statistics of the mouse bone-marrow micronucleus test: counting, distribution and evaluation of results

Authors
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
0027-5107
Publisher
Elsevier
Publication Date
Volume
111
Issue
2
Identifiers
DOI: 10.1016/0027-5107(83)90063-5

Abstract

Abstract The distribution of historical control results from male mice tested in the bone-marrow micronucleus test was used to optimize counting procedures and to develop decision rules for evaluating test results. The ratio of normochromatic to polychromatic erythrocytes followed a normal distribution, while the incidence of micronucleated polychromatic and normochromatic erythrocytes followed a binomial distribution. Recommendations for the number of cells to be scored per animal and for the evaluation of results are based on these distributions and the two-hypothesis multiple-decision approach of Selby and Olsen (1981).

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Statistics of the mouse bone-marrow micronucleus t...

on Mutation Research/Fundamental... October 1983

Methyl carbamate: negative results in mouse bone-m...

on Mutation Research/Fundamental... August 1991

Comparison of results from mouse bone marrow chrom...

on Environmental and Molecular Mu... 1995

The mouse bone marrow micronucleus test: Evaluatio...

on Mutation Research/Genetic Toxi... Jan 01, 1989
More articles like this..