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Host range recombinants of fowl plague (influenza A) virus

Authors
Journal
Virology
0042-6822
Publisher
Elsevier
Publication Date
Volume
91
Issue
1
Identifiers
DOI: 10.1016/0042-6822(78)90356-2

Abstract

Abstract Recombinants between the influenza virus strains fowl plague virus (FPV, Hav1N1) and Hong Kong (H3N2) have been isolated which form plaques on MDCK cells but not on chick embryo cells, although they carry the hemagglutinin of FPV. These host range recombinants have been characterized and one of them has been used for a second recombination with virus N (Hav2Neq1) or equi 2 (Heq2Neq2) on chick embryo cells. In this way, recombinants were obtained with a mixed genome which have regained the natural host range of FPV and some pathogenic properties for chicken. The results are discussed as a possible mechanism for a pandemic influenza strain to survive in an animal reservoir by changing its host range by recombination, and to regain the original host range by a second recombination but always keeping the same hemagglutinin.

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