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Correction: Improvement of right heart structure and function by BAY41-8543 in pulmonary artery banded mice

Authors
Journal
BMC Pharmacology
1471-2210
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
11
Identifiers
DOI: 10.1186/1471-2210-11-s1-p80
Keywords
  • Correction
Disciplines
  • Biology
  • Medicine

Abstract

Correction: Improvement of right heart structure and function by BAY41-8543 in pulmonary artery banded mice CORRECTION Open Access Correction: Improvement of right heart structure and function by BAY41-8543 in pulmonary artery banded mice Wiebke Janssen1*, Yves Schymura1, Astrid Wietelmann1, Johannes-Peter Stasch3, Himal Luitel2, Norbert Weissmann2, Hossein Ardeschir Ghofrani2, Friedrich Grimminger2, Thomas Braun1, Werner Seeger1,2, Ralph Theo Schermuly1,2 From 5th International Conference on cGMP: Generators, Effectors and Therapeutic Implications Halle, Germany. 24-26 June 2011 Abstract P79 [1] was published in error and the correct text follows: Background Right heart failure is a prevalent mechanism of cardio- vascular collapse and distinctly different from left heart failure. Afterload reduction has been the main focus to treat right ventricular (RV) dysfunction, but it cannot be achieved in many cases. A new strategy is to directly target increased RV hypertrophy. Pulmonary artery banding (PAB) is used to induce the RV hypertrophy, without any changes in the pulmonary vasculature. The nitric oxide (NO) pathway was shown to be crucially involved in the development of left ventricular hypertro- phy. In this study we assessed the effects of the sGC sti- mulator BAY 41-8543, the PDE5 inhibitor sildenafil, and combination treatment on RV function and RV hypertrophy. Methods Chronic pressure-overload RV hypertrophy was induced by PAB in male C57/Bl6 wild-type mice. Drug treatment was started seven days after surgery for the duration of 2 weeks, after which the consequences of the sustained pressure overload on RV morphology and function were assessed using Magnetic Resonance Imaging (MRI) and RV catheterization. Furthermore, fibrosis was assessed by histology. Results Three weeks after PAB, placebo-treated mice showed several signs of RV dysfunction as compared to sham- operated mice. PAB led to RV systolic dysfunction, as indicated by an increase in end-systolic volume (17

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