Abstract Evidence suggests a physiological role of the GABA A receptor in the pancreas. Clinically, an autoimmune reaction involving the GABA biosynthesizing enzyme, glutamic acid decar☐ylase has been implicated in the development of insulin-dependent diabetes mellitus. To determine the subtypes of GABA A receptor expressed in human pancreas, we analyzed, with the use of the reverse-transcription/polymerase chain reaction technique human pancreatic tissue for the presence of GABA A receptor subunits α1–6, β1–3, and γ1–2 transcripts. Unlike brain tissue, pancreatic tissue only expresses the α2, β3 and γ1 subunits. Our results provide evidence of a specific GABA A receptor subtype expressed in human pancreatic tissue.