Affordable Access

Publisher Website

Chemoprophylaxis of bacterial infections in granulocytopenic patients

Authors
Journal
The American Journal of Medicine
0002-9343
Publisher
Elsevier
Publication Date
Volume
76
Issue
4
Identifiers
DOI: 10.1016/0002-9343(84)90289-4
Disciplines
  • Medicine

Abstract

Abstract Several prospectively randomized trials have shown that the administration of prophylactic oral nonabsorbable antibiotics may be beneficial in decreasing the incidence of infection in granulocytopenic patients, whereas others have not. Intolerable nausea and vomiting have prevented the prolonged use of these agents in some studies. Discontinuation of therapy while patients are still granulocytopenic has carried the risk of life-threatening infections, often with aminoglycoside-resistant gram-negative organisms. The benefit of selective decontamination with trimethoprim/sulfamethoxazole used prophylactically remains controversial. The use of trimethoprim/sulfamethoxazole may also be associated with the development of resistant, potentially pathogenic, organisms or prolonged neutropenia. These regimens do not appear to be indicated when patients are anticipated to be neutropenic for less than three weeks. Even in patients with prolonged neutropenia, the risks of such treatment must be weighed against potential benefits.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Chemoprophylaxis of bacterial infections in granul...

on Chemioterapia : international... October 1988

[Chemoprophylaxis of bacterial infections in granu...

on KansenshoŐĄgaku zasshi. The Jou... January 1995

Symposium on infectious complications of neoplasti...

on The American Journal of Medici... April 1984
More articles like this..