Brine-shrimp Bioassay for Assessment of Anticancer Property of Essential Oils from Spices

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Brine-shrimp Bioassay for Assessment of Anticancer Property of Essential Oils from Spices

Authors
Publisher
Nepal Academy of Science and Technology (RONAST)
Publication Date
Keywords
  • Medicine
  • Toxicity
  • Essential Oil
  • Plant Science
  • Spice
  • Animal Science
  • Anticancer
  • Artemia Salina
  • Brine-Shrimp Bioassay

Abstract

The potential anticarcinogenicity of essential oils from spices was investigated against brine-shrimp (Artemia salina) nauplii. The essential oils were extracted by hydro-distillation. The lethal concentration at the dose levels 10, 100 and 1000 ìg/ml displayed high mortality towards actively swarming Artemia. Asafoetida (LC50 = 4.64 ×10–23 ìg/ml) and cumin oil (LC50 = 0.53 ìg/ml) were extremely toxic. Essential oils of ajowan, small cardamom, cinnamon, clove, coriander, cubeb, dill, fennel, ginger, mace, nutmeg, long pepper, rosemary, tarragon and thyme were shown high toxicity. While big cardamom oil and black pepper oil were displayed moderate toxicity.DOI: http://dx.doi.org/10.3126/njst.v12i0.6495 Nepal Journal of Science and Technology 12 (2011) 163-170

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