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D4receptor deficiency in mice has limited effects on impulsivity and novelty seeking

Authors
Journal
Pharmacology Biochemistry and Behavior
0091-3057
Publisher
Elsevier
Publication Date
Volume
90
Issue
3
Identifiers
DOI: 10.1016/j.pbb.2008.03.013
Keywords
  • Impulsivity
  • D4Receptors
  • Mice
  • Delay Discounting
  • Go/No-Go
  • Inhibition
  • Novelty Seeking
  • Locomotion
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Alleles of the human dopamine D 4 receptor (D 4R) gene (DRD4.7) have repeatedly been found to correlate with novelty seeking, substance abuse, pathological gambling, and attention-deficit hyperactivity disorder (ADHD). If these various psychopathologies are a result of attenuated D 4R-mediated signaling, mice lacking D 4Rs (D 4KO) should be more impulsive than wild-type (WT) mice and exhibit more novelty seeking. However, in our study, D 4KO and WT mice showed similar levels of impulsivity as measured by delay discounting performance and response inhibition on a Go/No-go test, suggesting that D 4R-mediated signaling may not affect impulsivity. D 4KO mice were more active than WT mice in the first 5 min of a novel open field test, suggesting greater novelty seeking. For both genotypes, more impulsive mice habituated less in the novel open field. These data suggest that the absence of D 4Rs is not sufficient to cause psychopathologies associated with heightened impulsivity and novelty seeking.

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