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Determination of aliphatic anhydrides and acids by reversed-phase liquid chromatography

Authors
Journal
Journal of Chromatography A
0021-9673
Publisher
Elsevier
Publication Date
Volume
868
Issue
1
Identifiers
DOI: 10.1016/s0021-9673(99)01101-2
Keywords
  • Aliphatic Anhydrides
  • Aliphatic Acids
Disciplines
  • Chemistry

Abstract

Abstract Few chromatography methods have been reported for the determination of anhydrides in mixtures or as mixed anhydrides. The potential reactivity of anhydrides with water and other common eluent components complicates possible schemes for separation and analysis. By optimizing variables that affect hydrolysis, including the stationary phase, conditions can be found to successfully analyze anhydrides as reactive as acetic anhydride. The corresponding acids can be determined at the same time. The effect of the stationary phase on anhydride hydrolysis rates may prove to be a sensitive means of probing stationary phase chemistry.

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