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Strychnine sensitive inhibition in the dorsal horn of mammalian spinal cord

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
217
Issue
2
Identifiers
DOI: 10.1016/0006-8993(81)90023-8
Keywords
  • In Vitro Spinal Cord
  • Inhibition
  • Strychnine
  • Picrotoxin
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract Using an in-vitro mammalian spinal cord preparation 3 pharmacologically distinct phases of inhibition have been demonstrated in the dorsal horn. An early picrotoxin-sensitive inhibition was followed by an intermediate strychnine-sensitive phase and a late phase resistant to both strychnine and picrotoxin. The picrotoxin-sensitive inhibition was accompanied by an increase in excitability of the afferent fibres which was prolonged by strychnine, suggesting the presence of glycine mediated inhibition of GABA primary afferent depolarization.

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