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Effect of TGFβ on liver genes expression Antagonistic effect of TGFβ on IL-6-stimulated genes in Hep 3B cells

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
301
Issue
1
Identifiers
DOI: 10.1016/0014-5793(92)80197-o
Keywords
  • Transforming Growth Factor β
  • Interleukin-6
  • Liver Gene Expression
  • Cytokine
Disciplines
  • Biology

Abstract

Abstract The effect of transforming growth factor beta (TGFβ) on the expression of a group of liver genes has been investigated in the hepatoma cell line Hep 3B. TGFβ induces a decrease of the basal level of apolipoprotein A-II (ApoA-II), retinol binding protein (RBP) α-fetoprotein (αFp). Furthermore, TGFβ efficiently antagonizes the IL-6-induction of hemopexin (Hpx) and haptoglobin (Hp) and α1-acid glycoprotein (AGP). These effects of TGFβ are apparently mediated by post-transcriptional mechanism(s). These findings, together with previously reported data on the inhibitory effect of TGFβ on acute phase genes (e.g. ApoA-I and albumin), suggest a role for TGFβ in the regulation of expression of liver genes.

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