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Temperature induced aggregation in aqueous solution of a series of PEO–PPO–PEO copolymers

Authors
Journal
International Journal of Pharmaceutics
0378-5173
Publisher
Elsevier
Publication Date
Volume
174
Identifiers
DOI: 10.1016/s0378-5173(98)00223-3
Keywords
  • Temperature Induced Aggregation
  • Dye Incorporation Uv Spectroscopy
  • Onset Temperature
  • Temperature Maxima
  • Copolymers

Abstract

Abstract The temperature induced aggregation phenomena of a series of poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) block copolymers (poloxamers) were investigated using dye incorporation UV spectroscopy, over a range of mass concentrations (0.1–15 mg ml −1). Initial experiments were performed using two different dyes (1,6-diphenyl-1,3,5-hexatriene (DPH) and I 2) so that the performance of each indicator for studying poloxamer aggregation could be determined. Subsequently, the onset temperatures ( T o) and temperature maxima ( T m) for the aggregation processes of 19 poloxamers were determined, using I 2 as an indicator. The aggregation temperature was observed to be dependent on both molecular mass and solution concentration for polymers comprising the same percent PEO, the aggregation temperature decreasing with increasing mass and/or increasing concentration.

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