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Induction of the c-fosproto-oncogene in rat amygdala during unconditioned and conditioned fear

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
565
Issue
2
Identifiers
DOI: 10.1016/0006-8993(91)91669-r
Keywords
  • C-Fos
  • Mrna
  • Amygdala
  • Fear
  • Conditioning
  • Rat

Abstract

Abstract Induction of the nuclear proto-oncogene c- fos in rat amygdala was investigated 30–40 min following the presentation of mild footshocks (unconditioned fear) or of contextual cues associated with similar footshocks 24 h earlier (conditioned fear). Initially, it was found that handling rats for the first time elevated c- fos mRNA levels, but this response could be blocked completely by repeated handling. Unconditioned and conditioned fear both elevated amygdala c- fos mRNA dramatically above control levels.

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