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Interactions between dendritic cells and CD4+ T cells during Plasmodium infection

Authors
Journal
Malaria Journal
1475-2875
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
7
Issue
1
Identifiers
DOI: 10.1186/1475-2875-7-88
Keywords
  • Research

Abstract

Background During infection, dendritic cells (DCs) encounter pathogenic microorganisms that can modulate their function and shape the T cell responses generated. During the process of T cell activation, DCs establish strong, long-lasting interactions with naïve T cells. Methods Using a mouse malaria model, the interactions of DCs and naïve CD4+ T cells have been analysed. Results DCs, either incubated in vitro with infected erythrocytes or isolated from infected mice, are able to present exogenous antigens by MHC-II, but are not able to establish prolonged effective interactions with naïve CD4+ T cells and do not induce T cell activation. It was also found that effective T cell activation of naïve CD4+ T cells is impaired during late Plasmodium yoelii infection. Conclusion These data may provide a mechanism for the lack of effective adaptive immune responses induced by the Plasmodium parasite.

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