Affordable Access

Publisher Website

Deficits in multiple systems of working memory in schizophrenia

Authors
Journal
Schizophrenia Research
0920-9964
Publisher
Elsevier
Publication Date
Volume
27
Issue
1
Identifiers
DOI: 10.1016/s0920-9964(97)00074-1
Keywords
  • Central Executive Model
  • Multiple Frontal Pathways Model
  • Working Memory
  • Schizophrenia
Disciplines
  • Law

Abstract

Abstract Working memory, the ability to hold and manipulate information ‘on-line’ in a temporary memory store, is impaired in schizophrenia. This impairment may be characterized within the framework of two opposing theoretical models: (1) central executive as coordinator of component processes of working memory or (2) multiple independent systems of spatial and object memory. In order to test which of these models better explains the working memory deficit of schizophrenia, 14 schizophrenic patients and 12 age-and gender-matched control subjects performed tests of spatial memory (dot location), object memory (shapes, color dots) and a dual paradigm (dot location + shapes). If schizophrenia impairs the central executive, a group-by-task interaction would demonstrate excessively worse performance on the dual than single tasks in schizophrenics relative to controls; however, the absence of an interaction would be consistent with deficits in the multiple working memory systems. The schizophrenic group was significantly impaired on all measures, and both the schizophrenic and control performance was worse on the dual than the single tasks. Despite the schizophrenic group performance deficits on the single tasks, the extent of such deficit did not appear additive and contributive to the dual tasks. The lack of a group-by-task interaction provided no support for the central executive model of dysfunction. Rather, the results uphold the model of working memory deficits arising from compromise of multiple (here spatial and object), relatively independent systems, both of which are affected in schizophrenia.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Deficits in multiple systems of working memory in...

on Schizophrenia research Oct 17, 1997

Word and tone working memory deficits in schizophr...

on Archives of General Psychiatry December 1998

Deficits of spatial working memory in chronic schi...

on Schizophrenia Research Jan 01, 2002
More articles like this..