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Cell Cycle-Dependent Activation of Telomerase in Naturally Synchronized Culture of a True Slime Mold,Physarum polycephalum

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
232
Issue
2
Identifiers
DOI: 10.1006/bbrc.1997.6327

Abstract

Abstract Telomeres of Physarumplasmodia did not shorten with numerous repeats of nuclear division, and an apparent activity of telomerase was detected in this organism. In naturally synchronized culture of Physarumplasmodia, an evident activation of telomerase was observed at the late S-phase, just prior to the completion of in vivoDNA replication, and the low telomerase activity was detected throughout the cell cycle. In the nuclei isolated from different phases of synchronized plasmodia, a higher activity of telomerase was also observed at late S-phase. These results clearly show the existence of a cell cycle-dependent regulatory mechanism of telomerase activity in growing, naturally synchronized cells.

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