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Luteinizing hormone releasing hormone agonists induce ovulation in hypophysectomized proestrous rats: Direct ovarian effect

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
29
Issue
2
Identifiers
DOI: 10.1016/0024-3205(81)90287-3
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract LHRH, and to a greater extent, selected LHRH agonists, induced ovulation in a dose-related fashion in the animal devoid of its pituitary gland and in the confirmed absence of serum LH. In view of the greater doses of LHRH and agonists required to induce ovulation in the hypophysectomized rat, coupled with a decrease in the maximum number of ova shed, it appears that this direct action represents a secondary pharmacological effect differing from the ovulation-inducting mechanism of these compounds in the intact animal. These data are in contrast to studies in which the agonists have been shown to produce direct inhibitory effects on the gonad; they provide an additional complicating aspect to these analogs' reproductive pharmacologic profile.

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