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Counting of lymphocyte subpopulations using standard versus low-dose antiCD3 monoclonal antibody treatment

Authors
Journal
Transplantation Proceedings
0041-1345
Publisher
Elsevier
Publication Date
Volume
36
Issue
6
Identifiers
DOI: 10.1016/j.transproceed.2004.06.019

Abstract

Abstract The monoclonal anti-CD3 antibody is used as part of prophylaxis and also in treatment of rejection. In the present article we analyzed changes in different lymphocyte subpopulations after anti-CD3 treatment. T lymphocytes were decreased under anti-CD3 antibody administration, with a simultaneous increase in B lymphocytes but no changes in natural killer (NK)cells. No differences were found between patients administered anti-CD3 antibody (Ab) at 5 versus 2.5 mg/d. It is uncertain whether these changes may be implicated in the lack of response or in the prophylactic effects of anti-CD3 Ab.

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