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Characterization of mapacalcine-sensitive Ca2+channels in rat kidney

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
308
Issue
3
Identifiers
DOI: 10.1016/s0006-291x(03)01432-3
Keywords
  • Kidney
  • Calcium Channels
  • Mapacalcine
  • Receptors
  • Binding
  • Autoradiography
  • Nephron
  • Nephrology
  • Adrenal Gland
Disciplines
  • Biology

Abstract

Abstract Mapacalcine receptors have been found to be associated with a Ca 2+ permeability insensitive to all known calcium blockers. Recently, high densities of mapacalcine receptors have been detected in the choroid plexus of rat brain. To determine a possible role for these channels, we have investigated their presence on other structures which, like choroid plexus, are involved in the secretion of biological fluids. Our data demonstrate that there are specific mapacalcine receptors on kidney membranes and glomeruli preparations. The mapacalcine receptors were present in all structures of the kidney. However, autoradiographic data demonstrated that superficial part of the cortex was more labeled than the other part of the kidney. These data would suggest that mapacalcine receptors could play a role in calcium homeostasis.

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