Affordable Access

Publisher Website

Short-term effects of 3,4-methylenedioximethamphetamine on noradrenergic activity in locus coeruleus and hippocampus of the rat

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
337
Issue
3
Identifiers
DOI: 10.1016/s0304-3940(02)01252-1
Keywords
  • 3
  • 4-Methylenedioxymethamphetamine
  • α2-Adrenoceptors
  • Locus Coeruleus
  • In Vivo
  • Tyrosine Hydroxylase Activity
  • Single-Unit Extracellular Recordings
  • Hippocampus

Abstract

Abstract This study was undertaken to investigate the effects of the administration of 3,4-methylenedioxymethamphetamine (MDMA) on the locus coeruleus firing rate, on the sensitivity of the α 2-adrenoceptors which regulate neuronal activity and on the in vivo tyrosine hydroxylase activity in hippocampus. The basal firing rate was not modified by either a single dose or repeated doses of MDMA, although the latter produced a shift to the right in the dose-response curve for clonidine-induced inhibition of the firing rate (ED 50 increased by 59%) and a reduction in tyrosine hydroxylase activity (20%) in the hippocampus. However, 8 days after the final dose α 2-adrenoceptor sensitivity and tyrosine hydroxylase activity had returned to control values. Our results show a desensitization of α 2-adrenoceptors in locus coeruleus and the existence of short-term changes in the noradrenergic system.

There are no comments yet on this publication. Be the first to share your thoughts.