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GK-22 amide: a novel myotropic peptide from the skin secretion of the bamboo leaf odorous frog, Odorrana versabilis

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  • The Skin Secretions Produced By Many Amphibians Are Formidable Chemical/Biological Weapons Deployed
  • Bioactive Peptides Are Often The Predominant Class Of Biochemical Within These Secretions And The In
  • Such As Bradykinins And Tachykinins
  • These Secretions Have Been The Source Of Many Peptides Subsequently Found To Have Structural Homolog
  • Sauvagine/Crf
  • Caerulein/Cck) And Vice Versa (Bradykinin
  • Cgrp
  • Nmu)
  • They Are Thus Unequivocally Intriguing Resources For Novel Bioactive Peptide Discovery
  • Here We Describe A Novel 22-Mer Amidated Peptide
  • Named Gk-22 Amide (N-Terminal Gly (G) And C-Terminal Lys (K) Amide) With An Internal Disulphide Brid
  • Molecular Cloning Indicated That It Is Encoded As A Single Copy On A Biosynthetic Precursor Of 59 Am
  • An Acidic Amino Acid Residue-Rich Spacer Domain And A Mature Peptide Encoding Domain Flanked N-Termi
  • A Synthetic Replicate Of This Peptide Produced Potent And Dose-Dependent Contraction Of The Smooth M
  • Gk-22 Amide Thus Represents The Prototype Of A Novel Class Of Myotropic Peptide From Amphibian Skin
  • Musicology


2013 - 2014 ...real solutions for communities ENGAGE Welcome to The SCIENCE SHOP Welcome to the third edition of the Science Shop ezine Engage. We hope that you enjoy reading about some of the community projects we have worked on with students during the past year. The Science Shop is a community research resource working with voluntary and community sector organisations right across Northern Ireland. We hope this information will help you think about your own research needs. Please contact us if you would like to discuss a project idea or would like more information about what we do. University of Ulster Science Shop ( 028 7167 5448 * [email protected] Queen’s University Belfast Science Shop ( 028 9097 3107 * [email protected] Music to their ears Sustainable NI are interested in how to work effectively with local groups to help them build sustainable communities. Students from the School of Geography at Queen’s worked with nine community groups across Northern Ireland piloting workshops examining issues such as water management, sustainable transport, energy management and waste issues. The students examined different methodologies for encouraging Twenty final year Ulster Music students took up the challenge to work with Science Shop community partners for their music in the community module. Rachel Houston and Michael Norton, worked in partnership with Foyle Downs Syndrome Trust, helping the group offer children music and singing classes after school. For eight weeks the students facilitated workshops that were thoroughly enjoyed by the Primary school participants, their siblings and parents. Rachel and Michael are pictured at Ulster Graduation in the Millennium Forum in July. Encouraging communities to make sustainable lifestyle choices local communities to consider reducing their impact on the environment. They concluded that different age groups responded differently to w

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