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O011: Reduction of resistance by sublingual administration of antimicrobials

Authors
Publisher
BioMed Central
Publication Date
Volume
2
Identifiers
DOI: 10.1186/2047-2994-2-s1-o11
Keywords
  • Oral Presentation
Disciplines
  • Medicine
  • Pharmacology

Abstract

O011: Reduction of resistance by sublingual administration of antimicrobials ORAL PRESENTATION Open Access O011: Reduction of resistance by sublingual administration of antimicrobials B Catry1*, H Laevens2 From 2nd International Conference on Prevention and Infection Control (ICPIC 2013) Geneva, Switzerland. 25-28 June 2013 Introduction Changing an antimicrobial regimen has shown to influ- ence the emergence of antimicrobial resistance, in which the regimen consists of the dose, the treatment interval, the duration of therapy, and the formulation. There is substantial evidence to encourage the use of high dose as short as possible, with a small and regular treatment interval to minimise the risk for the selection of resis- tant mutants. However, in contrast with these first three aspects of the antimicrobial regimen, little attention is currently paid to ‘formulation’ in relation to guidelines for a rational antimicrobial therapy to maintain clinical efficacy while reducing the opportunity of resistant strains to have a selective advantage. Formulations of antimicrobial agents have been adjusted in function of the route of administration, which can be local (topical) or systemical. Systemical concentrations of a certain antimicrobial molecule can be achieved either through oral, sublingual, rectal or injectable administration. Objectives The purpose of this work is to explore the different routes of administration with regard to the stimulation of antimicrobial resistance. Methods The one health approach – combining expertise from human and veterinary – will be used throughout the pre- sentation for gathering evidence and exploring potential for the application. Results The author invites the audience to examine the poten- tial manufacturing of sublingual (and rectal) application as alternatives for antimicrobial therapy. Advantages will be explained by terms of correct dosing and timing, compliance and side effects, influence of feed intake on pharmacokinetics (absorptio

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