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Close relationships between in vitro ADMET and DMPK research in pre-clinical drug discovery

Authors
Publisher
International Association of Physical Chemists; [email protected]
Publication Date
Keywords
  • Admet
  • Dmpk
Disciplines
  • Medicine
  • Pharmacology

Abstract

jESE manuscript doi: 10.5599/admet.1.1.1 1 ADMET & DMPK 1(1) (2013) 1-2; doi: 10.5599/admet.1.1.1 Open Access : ISSN: 1848-7718 http://www.pub.iapchem.org/ojs/index.php/admet/index Editorial Close relationships between in vitro ADMET and DMPK research in pre-clinical drug discovery Kin Tam Editor: ADMET & DMPK E-mail: [email protected] Received: December 20, 2012; Revised: January 10, 2013; Published: January 14, 2013 I have recently been invited to become an editor of a new open-access journal, ADMET & DMPK. I am honored to take up this exciting and challenging position. At first glance, the journal name is just a combination of two acronyms/disciplines in the pharmaceutical industry: ADMET (absorption, distribution, metabolism, excretion and toxicology) and DMPK (drug metabolism and pharmacokinetics), which sounds odd. Practically speaking, ADMET refers to a suite of in vitro assays that address various aspects of the pharmacokinetic performance of a drug, while DMPK more often refers to a drug’s in vivo pharmacokinetic performance. On thinking about it in more depth, it makes perfect sense to consider these two disciplines together, as a good DMPK profile of a drug candidate would be difficult to achieve without optimal ADMET properties, and both play an indispensable role in pre-clinical drug discovery. Here, I will share my views on the synergistic roles of these two disciplines, and how our new journal might help to foster the development of ADMET and DMPK. The discovery and development of a new candidate drug is a resource intensive and challenging process in the pharmaceutical industry. It involves evaluating the parameters affecting the likely success of a drug candidate in the preclinical, clinical and commercial phases of drug development. To maximize the chance of success in the clinic, it is crucial to generate and optimize quality lead compounds in the discovery phase. Ideally, the discovery project should include

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