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Antimicrobial activity of organotin(IV) complexes with the ligand benzilbis(benzoylhydrazone) and 4,4′-bipyridyl as coligand

Authors
Journal
Journal of Inorganic Biochemistry
0162-0134
Publisher
Elsevier
Publication Date
Volume
105
Issue
5
Identifiers
DOI: 10.1016/j.jinorgbio.2011.01.014
Keywords
  • Hydrazones
  • Organotin(Iv) Complexes
  • Antimicrobial Activity
  • Crystal Structure
Disciplines
  • Philosophy

Abstract

Abstract Several methyltin(IV) and butyltin(IV) complexes with the ligand benzil bis(benzoylhydrazone) and 4,4′-bipyridyl as coligand were synthesised and characterized by elemental analysis and by IR, 1H, 13C and 119Sn NMR spectroscopies. Some of them were also analyzed using single crystal X-ray diffraction. The title compounds were evaluated for their in vitro antimicrobial properties. All buthyltin complexes showed significant inhibition of Gram positive bacteria, resulting Bacillus subtilis, Sarcina lutea and both methicillin-susceptible and methicillin-resistant Staphylococcus epidermidis the most sensitive strains. Furthermore, they were able to inhibit the growth of Gram negative bacteria, especially Proteus vulgaris, whereas no activity was exhibited against fungi. All methyltin complexes were devoid of antimicrobial properties.

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